Vážený pane kolego, paní kolegyně,
dovolujeme si Vás pozvat na přednášku bioinformatického semináře, která
se koná tuto středu 20.4.2016 od 17:20 v posluchárně S5 na Malé straně.
Přednášku na téma
How genomes help us understand human history
přednese
Stephan Schiffels,
Max Planck Institute
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Se srdečným pozdravem
Petr Daněček a Martin Loebl
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Abstract: The availability of complete human genome sequences from
populations across the world has given rise to new population genetic
inference methods that allow unprecedented insight into human population
history. Here I will introduce two such methods that allowed us to infer
historical human population sizes and the emergence of population
substructure across the world. The first method, MSMC, explicitly models
ancestral relationships under recombination and mutation of multiple
genome sequences. Results from applying MSMC to genome sequences from
nine populations across the world suggest that the genetic separation of
non- African ancestors from African Yoruban ancestors started long
before 50,000 years ago and give information about human population
history as recent as 2,000 years ago, including the bottleneck in the
peopling of the Americas and separations within Africa, East Asia and
Europe. The second method, rarecoal, infers population history and
identifies fine-scale genetic ancestry from rare genetic variants. I
show an application of this method to ancient DNA retrieved from British
skeletons dating to the Iron Age and the Anglo-Saxon period. Using
rarecoal we find that the Anglo-Saxon samples are closely related to
modern Dutch and Danish populations, while the Iron Age samples share
ancestors with multiple Northern European populations including Britain.