Dear all,

the next seminar will take place next week, please see the details below. We look forward to seeing you all!

Title: AlphaFold DB, Increasing the structure coverage of the sequence space by a thousand times Speaker:  Mihaly Varadi, EMBL

Date and time: Wednesday 23/11/2022 - 17:20 Location: MFF UK, Malostranské nám. 25, lecture hall S6 https://bioinformatika.mff.cuni.cz/seminar/

Best wishes, Petr Danecek

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*Mihaly Varadi* */AlphaFold DB: Increasing the structure coverage of the sequence space by a thousand times/*

I will give a brief introduction about why (predicted) protein structures can be useful, and then talk briefly about how the protein structure prediction field grew over the years. I will also talk about AlphaFold, its strengths and weaknesses, and explain the various types of output coming from the AI, in particular about the various confidence measures. Then I'll talk about the database (what types of data, what technology, how to access the data) and then briefly about the place of AlphaFold DB in the wider context of other predicted protein structure providers and initiatives such as the 3D-Beacons.