Dear all,
the next seminar will take place on Wednesday, please see the
details below. We look forward to seeing you all!
Title: From human population variation to ligand binding sites via
SARS-CoV-2
Speaker: Geoff Barton (University of Dundee)
Date and time: Wednesday 17/04/2024 - 17:20
Location: MFF UK, Malostranské nám. 25, lecture hall S4
https://bioinformatics.cuni.cz/seminar/
Best wishes,
Petr Danecek
-------------------------------
Geoff Barton (University of Dundee)
From human population variation to ligand binding sites via
SARS-CoV-2
In this talk I will present an analysis that compares publicly
available variation data for human with variation seen across all
available protein sequences regardless of species. The analysis
confirms patterns of variation in human are consistent with protein
structural features (e.g. alpha-helix and begta-strand) but
highlights structurally and functionally important sites in around
15,000 human protein domains that are not found by conventional
sequence analysis methods. The identified sites are enriched in
disease-associated variants, ligand binding residues and
protein-protein interaction sites.
I will explain the method and illustrate the new analysis with
examples including the Nuclear Receptor Ligand Binding Domains and
G-protein coupled receptors (GPCRs) which are important therapeutic
targets.
The study makes heavy use of the popular Jalview (www.jalview.org)
sequence analysis program developed since 1996 in my group, so I
will also give a brief update on Jalview’s new features for
exploring nsSNPs on alignments and three-dimensional structures
including predictions by AlphaFold.