Dear all,
the next seminar will take place tomorrow, please see the details below. We look forward to seeing you all!
Title: Augusta, a Python package for inferring Gene Regulatory and Boolean Networks using RNA-Seq and data mining Speaker: Jana Musilová (Brno University of Technology)
Date and time: Wednesday 22/11/2023 - 17:20 Location: MFF UK, Malostranské nám. 25, lecture hall S3 https://bioinformatics.cuni.cz/seminar/
Best wishes, Petr Danecek
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*Jana Musilová (Brno University of Technology)* */Augusta, a Python package for inferring Gene Regulatory and Boolean Networks using RNA-Seq and data mining/*
Augusta is an open-source Python package for Gene Regulatory Network (GRN) and Boolean Network (BN) inference, based on a unique approach combining laboratory-generated data processing with the additional knowledge incorporation. In detail, the first estimation of a GRN is inferred by mutual information calculation from the high-throughput gene expression data. Subsequently, the GRN is refined by predicting transcription factor binding motifs within the promoters of regulated genes and integrating verified interactions obtained from curated databases. The refined GRN is finally transformed into a draft BN by searching in the curated model database CellCollective and adding logical rules to individual edges.