Dear all,
the next seminar will take place this Wednesday, please see the details
below. We look forward to seeing you all!
Best wishes,
Petr Danecek
Date and time: Wednesday 20/04/2022 - 17:20
Location: MFF UK, Malostranské nám. 25, lecture hall S6
https://bioinformatika.mff.cuni.cz/seminar/
Title: Sequence space and protein functional classification
Speaker: Alessandra Carbone
Affiliation: Department of Computational and Quantitative Biology,
Sorbonne University
Abstract:
Functional classification of proteins from sequences alone has become a
critical bottleneck in understanding the myriad of protein sequences
that accumulate in our databases. The great diversity of homologous
sequences hides, in many cases, a variety of functional activities that
cannot be anticipated. Their identification appears critical for a
fundamental understanding of the evolution of living organisms and for
biotechnological applications.
In this talk, I will explain how rethinking the sequence space with
multiple profile models leads to the functional classification of
proteins. I will present ProfileView, a sequence-based computational
method designed to functionally classify sets of homologous sequences.
ProfileView relies on two main ideas: the use of multiple profile models
whose construction explores evolutionary information in available
databases, and a novel definition of a representation space in which to
analyse sequences with multiple profile models combined together.
ProfileView classifies protein families by enriching known functional
groups with new sequences and discovering new groups and subgroups.